The first Redemptorists in Haiti, coming from the Lesser Antilles (which was ministered by the Belgian Redemptorists), arrived in Haiti in 1929 to preach popular missions. They settled in Port-au-Prince where they built the Monastery of Saint Gérard, in Carrefour-Feuilles, then in Fonds-des-Nègres where they founded the parish of Saint-Joseph in the diocese of Les Cayes. Thanks to these two mission centers, they preached popular missions throughout almost the entire country.

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In 1980, given their old age and the lack of additional personnel, the Belgian Redemptorists ministering in Haiti could no longer continue the mission in Haiti, so the General Government of the Order at that time decided to entrust the mission in Haiti to the French-speaking Canadian Province of Sainte-Anne-de-Beaupré, which established this mission as the Redemptorist Region of Port-au-Prince on September 11, 1984.

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The Region transferred its affiliation from Canada to the Province of San Juan de Puerto Rico on June 27, 2018. This province would later be merged with the existing Redemptorist regions in Central America, becoming the Province of Our Mother of Perpetual Help - Central America and Caribbean on September 11, 2023.